Clinical observation on effect of shenle capsule in treating mesangial proliferating glomerulonephritis.
- Author:
Chen-yun WEI
1
;
Xiang-mei CHEN
;
Yan-ping ZHANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; therapeutic use; Benzazepines; therapeutic use; Child; Cholesterol; blood; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Glomerulonephritis, Membranoproliferative; blood; drug therapy; Humans; Male; Middle Aged; Phytotherapy; Proteinuria; drug therapy; Triglycerides; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):341-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the therapeutic effect of Shenle capsule (SLC) in treating mesangial proliferating glomerulonephritis (MsPGN) and to explore its therapeutic mechanism and clinical indication.
METHODSAdopting case control method, taking angiotensin-converting enzyme inhibitor (benazepril) as control agent, the 142 cases of MsPGN were randomly divided into 3 groups, treated with SLC (Group A, n = 36), SLC plus benazepril (Group B, n = 68) and benazepril alone (Group C, n = 38) respectively. Changes of fibrinogen, lipids, renal function and urinary protein were observed.
RESULTSThe total effective rate in Group A was higher than that in Group C, but with insignificant difference. The total effective rate in Group B after 3 courses of treatment was 89.74%, which was higher than that in Group C and Group A (P < 0.05). Levels of cholesterol (CH), triglyceride (TG), serum creatinine, fibrinogen and urinary protein (UP) were significantly lowered in Group A after treatment, with the levels of CH, TG and UP lower than those in Group C, while CH, TG and fibrinogen were unchanged in Group C after treatment.
CONCLUSIONSLC is superior in higher efficacy and less side-effects in treating MsPGN, its effect is related with the degree of kidney pathological changes, it is more effective in treating patients with mild pathological change than in those with severe change. The outcome of combined use of SLC and angiotensin-converting enzyme inhibitor would be better.
