Preliminary exploration on effect of yiqi wenyang huoxue lishui treatment on neuroendocrine system in patients with congestive heart failure.
- Author:
Hai-ying AN
1
;
Li-juan HUANG
;
Jing-shan JIN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Angiotensin II; blood; Atrial Natriuretic Factor; blood; Coronary Disease; complications; Drugs, Chinese Herbal; therapeutic use; Female; Heart Failure; drug therapy; etiology; physiopathology; Humans; Male; Middle Aged; Neurosecretory Systems; drug effects; P-Selectin; blood; Phytotherapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):349-352
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Yiqi Wenyang Huoxue Lishui principle (YWHL, a therapeutic principle with Chinese medicine for reinforcing Qi warming Yang, activating blood circulation and promoting urination) on some neuroendocrine factors in patients with congestive heart failure (CHF).
METHODSForty-nine patients of CHF with heart function of grade III-IV were randomly divided into 2 groups. The 29 cases in the treated group were treated with YWHL and the 20 cases in the control group treated with captopril. Changes of angiotensin II (AT II), atrial natriuretic peptide (ANP), endothelin (ET), nitric oxide (NO) and alpha-granule membrance protein -140 (GMP-140) were observed.
RESULTSAfter treatment, plasma level of AT II, ANP, ET, and NO lowered in both groups with insignificant difference, but the GMP-140 reduced more significantly in the treated group (P < 0.05).
CONCLUSIONYWHL showed a regulatory effect of neuroendicrine system partially similar to that of angiotensin-converting enzyme inhibitor, it possibly can improve the ventricular remodeling and would be beneficial to prevent the thrombus formation and improve heart failure by means of inhibiting platelet activity.
