Clinical study on effect and therapeutical mechanism of composite Salvia injection on acute cerebral infarction.
- Author:
Lian-qiu MIN
1
;
Li-ying DANG
;
Wei-yan MA
Author Information
- Publication Type:Clinical Trial
- MeSH: Aged; Apolipoprotein A-I; blood; Cerebral Infarction; drug therapy; Drugs, Chinese Herbal; therapeutic use; Female; Free Radical Scavengers; therapeutic use; Humans; Injections, Intravenous; Male; Middle Aged; Phytotherapy; Salvia miltiorrhiza; chemistry; Superoxide Dismutase; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):353-355
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the curative effect and therapeutical mechanism of composite salvia injection (CSI) in treating ischemic cerebral infarction in the respect of oxygen free radical and apolipoprotein.
METHODSSixty-eight cases of ischemic cerebral infarction within the first 72 hrs after onset were divided randomly into the CSI group (treated with CSI) and the control group (treated with Xueshuantong). Serum lipid peroxide (LPO) and superoxide dismutase (SOD) were measured by colorimetry and apolipoprotein A1 (ApoA1) and ApoB100 were measured with unidirectional immune diffusion method.
RESULTSSerum levels of LPO and ApoB100 were obviously lower, and levels of SOD and ApoA1 significantly higher in the CSI group than those in the control group (P < 0.05 or P < 0.01). The total effective rate of CSI in treating cerebral infarction was 88.24%, which was significantly higher than that of the control (P < 0.05).
CONCLUSIONCSI shows definite effect in treating cerebral infarction, to reduce the oxygen free radical damage and regulate the apolipoprotein metabolism possibly was the important therapeutical mechanism.
