Study on abnormality and regulation of T-lymphocyte subsets in peripheral blood of rheumatoid arthritis patients.

Author: Ying-nan LI ¹ ; Yu-song ZHAO ; Xiu LI
Author Information

1. Department of Rheumatoid Diseases, Second Affiliated Hospital, Harbin Medical University, Harbin 150086.
Publication Type:Clinical Trial
MeSH: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; therapeutic use; Arthritis, Rheumatoid; drug therapy; immunology; CD4-CD8 Ratio; Diclofenac; therapeutic use; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Male; Middle Aged; Phytotherapy; T-Lymphocyte Subsets; immunology
From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):359-361
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the change of T-lymphocyte subsets in peripheral blood of rheumatoid arthritis (RA) patients and analyze the effects of Fuzheng Qubi Decoction (FZQBD) on T-cell subsets.
METHODSThirty RA patients were randomly divided into two groups, and treated with FZQBD or western medicine combination therapy respectively for one month, the percentage of peripheral CD3+, CD4+, CD8+ as well as the serum IgG and IgA levels were determined.
RESULTSThe percentage of peripheral CD4+, CD4+/CD8+ ratio, IgG and IgA levels increased significantly (P < 0.001) in RA patients before treatment. After 1 month of FZQBD treatment, the CD4+/CD8+ ratio decreased obviously (P < 0.05).
CONCLUSIONAbnormal cellular immunity exists in RA patients, FZQBD could adjust the abnormal T-lymphocyte subsets to normalize it.