Effect of ligustrazine on bone marrow hematopoiesis in mice after bone marrow transplantation.
- Author:
Han-ying SUN
1
;
Ming-hao FANG
;
Tian-hua REN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Transplantation; Female; Hematopoiesis; drug effects; Leukocytes, Mononuclear; drug effects; Male; Mice; Mice, Inbred BALB C; Pyrazines; pharmacology; Random Allocation; Receptors, CXCR4; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):365-368
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of ligustrazine (LT) on hematopoiesis in mice after bone marrow isotransplantation (iso-BMT).
METHODSThe typical model of iso-BMT was established and the model mice were randomly divided into two groups, the LT group treated with LT injection 0.2 ml and the control group treated with normal saline 0.2 ml, twice a day by gastrogavage. The following parameters were observed in the day 1, 7 and 14: peripheral blood cells, bone marrow mono-nuclear cells (BMMNC), heparin sulfate (HS) expression in bone marrow section by immunohistochemical SABC-AP method, stromal cell derived factor-1 (SDF-1) expression and CXC chemotaxis factor receptor 4 (CXCR4) expression.
RESULTSThe levels of peripheral WBC, platelet, BMMNC, CXCR4, HS, SDF-1 at the day 7 and 14 in the LT group were all higher significantly than those in the control group (P < 0.05 or P < 0.01).
CONCLUSIONLT could improve the bone marrow hematopoiesis in the early hematopoietic re-establishing stage after BMT.
