Comparative study on effect of recipe for activating blood circulation and replenishing Qi on left ventricular remodeling in rats with left heart failure after myocardial infarction.
- Author:
Zhen-tao WANG
1
;
Shuo-ren WANG
;
Ming-jing ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astragalus membranaceus; Cardiac Output, Low; pathology; physiopathology; Drugs, Chinese Herbal; pharmacology; Male; Myocardial Infarction; pathology; physiopathology; Phytotherapy; Qi; Rats; Rats, Wistar; Ventricular Remodeling; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):376-378
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEComparative study to the effect of Chinese herbal medicine on left ventricular remodeling in rats with left heart failure after myocardial infarction (MI).
METHODSRat's model of left heart failure after myocardial infarction was treated with injection for activating blood circulation (ABCI, consisted of R. Salviae miltiorrhizea; Rh. Ligusticum wallichii and F1. Carthamus tinctorius) and injection for replenishing Qi (RQI, consisted of R. Codonopsis Pilosulae and R. Astragalus membranaceus) respectively. The effect of treatment were evaluated by observing and comparing the changes of heart morphological structure, collagen element, heart weight/body weight ratio (HW/BW), left intraventricular area (LVA), ratio of ventricular wall thinning in MI area and myocardial nuclei number (MNN) per square area.
RESULTSIn comparison with the model group, the reduction of collagen tissue around myocardial cells in living area of MI, HW/BW and LVA of ABCI and RQI group were lower, and MNN per square area was higher significantly (all P < 0.05).
CONCLUSIONBoth ABCI and RQI, though without positive myodynamia, showed certain inhibitory effect of left ventricular remodeling in rats with left heart failure after MI.
