Influence of combined therapy of guben yiliu III, moxibustion and chemotherapy on immune function and blood coagulation mechanism in patients with mid-late stage malignant tumor.
- Author:
Ju LIU
1
;
Ren-cun YU
;
Wu-jun TANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Antineoplastic Combined Chemotherapy Protocols; administration & dosage; therapeutic use; Blood Coagulation; Carboplatin; administration & dosage; Cisplatin; administration & dosage; Cyclophosphamide; administration & dosage; Doxorubicin; administration & dosage; Drugs, Chinese Herbal; therapeutic use; Etoposide; administration & dosage; Female; Fluorouracil; administration & dosage; Humans; Lung Neoplasms; blood; immunology; therapy; Lymphocyte Count; Male; Mitomycin; administration & dosage; Moxibustion; Phytotherapy; Stomach Neoplasms; blood; immunology; therapy; T-Lymphocyte Subsets
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(2):104-106
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the supplementary effect of moxibustion and Guben Yiliu III (GBYL), a Chinese herbal compound preparation, in combination with chemotherapy.
METHODSEighty-one patients of mid-late stage malignant tumor were randomly divided into 3 groups: 16 in Group A treated with chemotherapy and placebo; 35 in Group B treated with chemotherapy and GBYL and 30 in Group C treated with chemotherapy and GBYL plus moxibustion. The short-term effect of treatment, changes of blood picture, cell mediated immune function and blood coagulation in patients were observed.
RESULTSAfter chemotherapy, the lymphocyte count was significantly lowered in Group A and B (P < 0.01), but not in Group C (P > 0.05); lymphocyte subset T3 raised significantly in Group B; the average level of T-lymphocyte subsets was reduced in Group A while it increased in the other two groups; and a bi-directional regulation on plasma fibrinogen concentration was shown in Group C (P < 0.05).
CONCLUSIONMoxibustion prevented dropping of lymphocyte count caused by chemotherapy. Combination of GBYL and moxibustion could prevent the lowering of T-lymphocyte subsets caused by chemotherapy, and moxibustion could regulate bi-directionally the patients' abnormality in part of blood coagulation mechanism.
