Effect of wenjingtong composita on blood glucose and advanced glycosylation end products in sciatic nerve of streptozotocin-induced diabetic rats.
- Author:
Sai-shan GUO
1
;
Dai-yi TANG
;
Xiao-chun LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; metabolism; Diabetes Mellitus, Experimental; blood; metabolism; Diabetic Neuropathies; metabolism; Drugs, Chinese Herbal; pharmacology; Glycosylation; drug effects; Guanidines; pharmacology; Male; Random Allocation; Rats; Rats, Wistar; Sciatic Nerve; metabolism; Sciatic Neuropathy; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(2):119-121
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Wenjingtong Composita (WJTC) on blood glucose and advanced glycosylation end products (AGEs) in sciatic nerve of streptozotocin (STZ)-induced diabetic rats.
METHODSSTZ-induced diabetic rats were randomized to WJTC prevention group and WJTC treatment group. The levels of blood glucose and AGEs in sciatic nerve of the animals were checked after 12 weeks treatment and compared with that of aminoguanidine (AG) treatment group.
RESULTSBlood glucose level in the WJTC prevention and treatment group, and AGEs in sciatic nerve of the WJTC prevention group and the AG group were lower than those of the non-treated group (P < 0.01). Blood glucose level in the AG group was higher than that in the WJTC prevention group (P < 0.05), but was not significantly different from that in the non-treated group (P > 0.05).
CONCLUSIONWJTC might prevent diabetic peripheral neuropathy by decreasing blood glucose and inhibiting AGEs formation in sciatic nerve in STZ-induced diabetic rats.
