Experimental study on liver protective effect of Artemisia rupestris extract.
- Author:
Israpil
1
;
Abdiryim
;
Gulnar
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Artemisia; chemistry; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; drug therapy; prevention & control; Drugs, Chinese Herbal; therapeutic use; Female; Galactose; Male; Mice; Phytotherapy; Random Allocation; Rats; Rats, Wistar
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(2):126-128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the protective effect of Artemisia rupestris extract (ARE) on chemical liver injury and immunological hepatitis.
METHODSMice model of immunological hepatitis was established by lipopolysaccharide plus Bacillus Calmette-Guérin vaccine (BCG), and the models of liver injury was induced by D-galactosamine or carbon tetrachloride (CCl4) in mice and rats. The effects of ARE in preventing and treating immunological hepatitis and protecting liver injury were observed.
RESULTSARE significantly lowered the serum alanine transaminase (ALT) in immunological hepatitis (P < 0.05), CCl4 induced liver injury model mice and rats (P < 0.01), and in D-galactosamine induced liver injury mice (P < 0.05).
CONCLUSIONARE has significantly protective effect against chemical liver injury and could treat immunological hepatitis, but with no effect in preventing immunological hepatitis. These might be the partial pharmacologic basis for using ARE in treating hepatitis.
