Study on effect of Salvia injection in treating primary nephrotic syndrome and on endothelin and serum interleukin-2 receptor in children.
- Author:
Hua-ying BAO
1
;
Hui-lan YU
;
Lin WANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Endothelins; blood; Female; Humans; Infusions, Intravenous; Male; Nephrotic Syndrome; blood; drug therapy; Phytotherapy; Prednisone; therapeutic use; Receptors, Interleukin-2; blood; Salvia miltiorrhiza; chemistry
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(1):28-29
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect and mechanism of Salvia Injection (SI) in treating primary nephrotic syndrome (PNS) in children.
METHODSForty-four PNS children were randomly divided into conventional steroid treated group (20 cases) and conventional plus SI intervention treated group (24 cases), the levels of serum endothelin (ET), soluable interleukin-2 receptor (sIL-2R) were observed.
RESULTSBefore treatment, plasma ET and sIL-2R in PNS children were higher than those in healthy children significantly (P < 0.01). After treatment, the ET and sIL-2R levels were all obviously improved in both treated groups (P < 0.05) and the improvement in the conventional plus SI intervention treated group was more obvious, the difference between the two treated groups after treatment was significant (P < 0.05).
CONCLUSIONConventional treatment supplemented with SI could more effectively improve the levels of plasma ET and SIL-2R in treating PNS children, and hence alleviate the damage of renal tissue.
