Expression of YY 1 protein in human insulinoma and its clinical implication.
- Author:
Wen-Xia LI
1
;
Ye-En HUANG
;
Xiao-Xin SHI
;
Pei-Xin LIN
;
Zhen-Ning ZHOU
;
Yao-Zhong ZHANG
;
Hong SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Biomarkers, Tumor; metabolism; Cell Transformation, Neoplastic; Humans; Immunohistochemistry; Insulinoma; genetics; metabolism; Pancreatic Neoplasms; genetics; metabolism; YY1 Transcription Factor; genetics; metabolism
- From: Journal of Southern Medical University 2016;36(3):361-364
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of Yin Yang 1 (YY1) protein in human insulinoma and explore its clinical significance.
METHODSNineteen pancreatic neuroendocrine tumor tissue were collected from patients treated in Nanfang Hospital between 2000 and 2014. The protein expression of YY1 in benign and malignant insulinoma tissues were detected by immunohistochemistry.
RESULTSPositive expression for YY1 protein was detected in both benign and malignant tumor tissues, but the malignant tissues had a significantly greater intensity of YY1 expression than the benign tissues (P=0.042). The intensity of YY1 expression was positively correlated with the nature of the tumor, and the insulinomas with high expressions of YY1 had significantly greater malignant potentials (P=0.037).
CONCLUSIONThe high expression of YY1 protein is associated with the development of insulinima. YY1 may serve as a new tumor marker for detecting the malignant transformation of insulinoma.
