Mechanisms and effects of Abelmoschus manihot preparations in treating chronic kidney disease.
- Author:
Ping CHEN
1
;
Yigang WAN
;
Chaojun WANG
;
Qing ZHAO
;
Qingxue WEI
;
Yue TU
;
Xuejiao YIN
Author Information
1. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. meisu1990@126.com
- Publication Type:Journal Article
- MeSH:
Abelmoschus;
chemistry;
Animals;
Drugs, Chinese Herbal;
administration & dosage;
Humans;
Kidney;
drug effects;
metabolism;
Renal Insufficiency, Chronic;
drug therapy;
metabolism
- From:
China Journal of Chinese Materia Medica
2012;37(15):2252-2256
- CountryChina
- Language:Chinese
-
Abstract:
Abelmoschus manihot (AM) is a medicinal plant rich in twenty kinds of separated active bio-components including flavones, polysaccharides, trannic acid, and long chain hydrocarbons. Among these, total flavones of A. manihot (TFA) are the major active component. In this review, the mechanisms of Huangkui capsule will be discussed as a preparation of AM to treat chronic kidney disease (CKD) by improving immunological reaction, inflammation, renal fibrosis, and renal tubular epithelial injury. Additionally, it has been reported that Huangkui capsule can ameliorate some clinical symptoms, proteinuria, hematuria, and renal function in patients with common CKD, such as nephrotic syndrome, diabetic nephropathy, Henoch-Schönlein purpura nephritis, IgA nephropathy, and membranous nephropathy.
