Pharmacodynamics of water extracts from Atractylodes lancea before and after processing.
- Author:
Yanju LIU
1
;
Wenwen CHEN
;
Min ZENG
;
Kang XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Atractylodes; chemistry; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; pharmacology; Female; Intestine, Small; drug effects; Male; Rats; Rats, Sprague-Dawley; Spleen; drug effects; Urination; drug effects
- From: China Journal of Chinese Materia Medica 2012;37(15):2276-2279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pharmacological changes of Atractylodes lancea before and after processing and the processing mechanism on the basis of the pharmacological changes.
METHODThe model of dampness retention in the middle-jiao rats was established to determine small intestine peristalsis rate, GAS level, urine volume and AQP2 content from urine in different groups.
RESULTAll treatment groups showed increase in small intestinal peristalsis rate and GAS level. The bran-processed group showed significant difference from the negative group. The high dose A. lancea group showed increase in urine volume and decrease in urine AQP2 content in model rats, which were different from the negative group.
CONCLUSIONWater extracts from bran-processed A. lancea can obviously increase small intestinal peristalsis and GAS level, indicating that A. lancea has the effect for strengthening spleen and stomach after stir-baking with bran. Its impact on urine and urine AQP2 content in model rats demonstrates that its dryness of A. lancea is alleviated after stir-baking with bran.
