Chemical constituents of n-BuOH extract of Comastoma pedunculatum.
- Author:
Yongqi QIAO
1
;
Baosong CUI
;
Li TANG
;
Jiabao LIU
;
Shuai LI
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
analysis;
Flavones;
analysis;
isolation & purification;
Gentianaceae;
chemistry;
Saponins;
analysis;
isolation & purification;
Spectrometry, Mass, Electrospray Ionization
- From:
China Journal of Chinese Materia Medica
2012;37(16):2360-2365
- CountryChina
- Language:Chinese
-
Abstract:
Thirteen compoumds were isolated from the n-BuOH portion of the 70% ethanolic extract of Comastoma pedunculatum by a combination of various chromatographic techniques including silica gel, macroporous adsorbent resin, Sephadex LH-20, and preparative HPLC, of which nine were triterpenoid saponins and four were flavone C-glycosides. Their structures were elucidated by spectroscopic data as saikogenin F (1), 3-O-beta-D-fucopyranosylsaikogenin F (2), clinoposaponin XV (3), saikosaponin A (4), 6"-acetylsaikosaponin A (5), clinoposaponin I (6), bupleuroside I (7) , clinoposaponin XII (8) , saikoponin b3 (9), isovitexin (10) , swertisin (11) , isoorientin (12), 3',4',5-trihydroxy-7-methoxy-6-C-beta-D-glucopyranosyl-flavone (13). Compounds 1-10, 12-13 were all isolated from Comastoma genus for the first time.
