Clinical study on prevention efficacy of Jianpi Huatan Fang in treating non-alcoholic fatty liver disease in children.
- Author:
Fang WU
1
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Child; Drugs, Chinese Herbal; therapeutic use; Fatty Liver; drug therapy; metabolism; physiopathology; prevention & control; Female; Humans; Insulin Resistance; Lipid Metabolism; Liver; physiopathology; Male; Non-alcoholic Fatty Liver Disease
- From: China Journal of Chinese Materia Medica 2012;37(16):2465-2468
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVETo verify the clinical efficacy of Jianpi Huatan Fang in treating non-alcoholic fatty liver disease in children.
METHODSixty children patients with non-alcoholic liver disease were randomly assigned to 2 groups of 30 patients each , being treated with Jianpi Huatan Fang and the Vitamin E Recipe with a span of 3 months, respectively. The changes of the FINS, FPG, AST, ALT, TG, CHO, HDL, LDL, HOMA-IR, IAI after and before the treatments in both groups as well as the ultrasound imaging changes of liver were observed.
RESULTThe Chinese medicine group saw higher total effective rate (83.3%) than the Vitamin E group (46.7%) with statistic difference. In addition, after the treatments, both groups saw the significant decrease of the levels of serum lipid metabolic indexes and insulin resistance indexes. Both treatments could effectively enhance the function of liver, but Chinese medicine showed better efficacy. The Chinese medicine group also saw the decrease of ATC, TG, LDL and increase of HDL-C (P < 0.05 (see character in text) P <0.01) after the treatment, showing that the Chinese medicine could effectively enhance blood fat; while the Vit E group did not showed improvement in TC, LDL-C, HDL-C.
CONCLUSIONJianpi Huatan Fang showed good efficacy in treating non-alcoholic fatty liver in children with no observable toxic side effects, thus clinic use shall be recommended.
