Assessment on analgesic and anti-inflammatory effects of Tongjingbao optimal formula and analysis on its active components.
- Author:
Wei CAO
1
;
Xu-ying WANG
;
Yan CHEN
;
Jie SONG
;
Zhen-hai ZHANG
;
Xiao-bin JIA
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics; administration & dosage; analysis; Animals; Anti-Inflammatory Agents; administration & dosage; analysis; Chemistry, Pharmaceutical; Drugs, Chinese Herbal; administration & dosage; analysis; Dysmenorrhea; drug therapy; Female; Humans
- From: China Journal of Chinese Materia Medica 2012;37(17):2558-2562
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the analgesic and anti-inflammatory effects of Tongjingbao optimal formula and analyze its active components.
METHODAnimals were divided into the model group, the Tongjingbao granule group and the Tongjingbao optimal formula group. The mice dysmenorrhea model was induced by oxytocin, and their content of blood calcium and MDA, NO, PGE2 in uterus were determined to assess the analgesic and anti-inflammatory effects of different components in Tongjingbao optimal formula and their impacts.
RESULTAll components of Tongjingbao optimal formula could extend the dysmenorrhea incubation period of mice with dysmenorrhea, reduce their average writhing time, increase the writhing inhibition rate, lessen the content of blood calcium and MDA, PGE2 in uterus, and enhance the content of NO in uterus.
CONCLUSIONAll components of Tongjingbao optimal formula have the analgesic and anti-inflammatory effects, and different components show a synergistic effect in treating dysmenorrheal in many links.
