Effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats.
- Author:
Xiao-wen ZHI
1
;
Xian-ming SU
;
Wei-yi FENG
;
Hong-mei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Calcium; metabolism; Drugs, Chinese Herbal; administration & dosage; In Vitro Techniques; Injections; Mesenteric Arteries; drug effects; physiology; Rats; Rats, Sprague-Dawley; Vasodilation; drug effects
- From: China Journal of Chinese Materia Medica 2012;37(17):2607-2611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats.
METHODAn isolated vascular ring experiment was conducted to determine the changes in tension of vascular rings with a biological signal collection and analytical system.
RESULTDanhong injection had no impact on the tension of vascular rings. Danhong injection showed a significant vasodilatation effect on treated arteria rings of norepinephrine, and no remarkable impact was made on the effect without endothium. It showed notable effect on blood vessels treated with Ca(2+) and no significant impact on those treated with caffeine. It could inhibit NE-induced intracellular calcium from releasing and external calcium from inflowing. No effects of potassium channel blockers on aorta ring tensile force were found.
CONCLUSIONDanhong injection shows significant vasodilation effect, which mainly works through vascular smooth muscle. Its vasodilation effect may be related to inhibitory receptor, voltage-dependent Ca(2+)-release and IP3 receptor-mediated Ca(2 +)-influx.
