Genetic polymorphism of six short tandem repeat loci on the X chromosome in a Han race population in China.

Xue Feng; Yan Wang; Ying Fan; Bing YU; Sheng-bin LI

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Genetic polymorphism of six short tandem repeat loci on the X chromosome in a Han race population in China.

Author: Xue FENG ¹ ; Yan WANG ; Ying FAN ; Bing YU ; Sheng-bin LI
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1. Key Laboratory of National Ministry of Health for Forensic Sciences & Environment and Genes, Diseases Key Laboratory of the Education Ministry, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R.China.
Publication Type:Journal Article
MeSH: Asian Continental Ancestry Group; genetics; China; ethnology; Chromosomes, Human, X; genetics; Ethnic Groups; Female; Genetics, Population; Humans; Male; Polymorphism, Genetic; Population; Tandem Repeat Sequences; genetics
From: Chinese Journal of Medical Genetics 2006;23(1):92-94
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the alleles and genotype frequencies of 6 short tandem repeat (STR) loci DXS7130, DXS1214, DXS6799, DXS6804, DXS7424 and DXS7133 on the X chromosome in Chinese Han individuals living in Shaanxi province of Northwest China.
METHODSThe 6 X-chromosomal STR loci were typed by PCR, denatured polyacylamide gel electrophoresis and silver stain.
RESULTSAmong females from Xi'an Han population, the numbers of alleles in the 5 loci (DXS7130, DXS6799, DXS6804, DXS7424 and DXS7133) were detected to be 9, 6, 6, 7, and 7 respectively; the numbers of genotypes were 21, 14, 15, 17 and 12 respectively; and the number of alleles in the DXS1214 was 8. Exact tests demonstrated that genotype frequencies of females had no departure from Hardy-Weinberg equilibrium.
CONCLUSIONThe six loci of X-chromosomal STRs are appropriate for individual identification, paternity test involving in female child and for study in related disease.