The expression of mutation p53 gene from circulating cancer cells of peripheral blood and the clinical significance in detecting the patients with colorectal cancer.
- Author:
Guo-jian MA
1
;
Jian-nong ZHOU
;
Zong-li SHEN
;
Sen-qing CHEN
;
Yue-qing ZHU
;
Xiao-liu WU
;
Kai-xian XUE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; diagnosis; genetics; pathology; DNA, Neoplasm; analysis; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, p53; genetics; Humans; Male; Middle Aged; Neoplastic Cells, Circulating; metabolism; Tumor Suppressor Protein p53; genetics
- From: Chinese Journal of Medical Genetics 2006;23(2):186-188
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical significance of detecting p53 gene mutation expression in colorectal cancer cells of peripheral blood.
METHODSFlow cytometry (FCM) was used to detect p53 gene mutation expression in peripheral blood cancer cells of 128 patients with colorectal cancer. Experimental data were analyzed by SPSS (v.11.0) software.
RESULTSThe lymph node metastasis showed the significant difference statistically (P<0.01) between p53 positive and negative expression in the colorectal cancer patients. The mutation p53 expression associated with existing histological differentiation (r=0.8476, P<0.05). A lymph node metastasis difference was observed between left and right colorectal cancers of mutation p53 positive expression.
CONCLUSIONDetecting the mutation p53 expression in cancer cells of peripheral blood might be helpful to the early diagnosis of colorectal cancer.
