A study on K469E polymorphism of ICAM1 gene and ICAM1 plasma level in patients with coronary heart disease.
- Author:
Fang-hong LU
1
;
Qing SHANG
;
Pei-e WEN
;
Guo-hai SU
;
Jian-mei WU
;
Qi TIAN
;
Ying-xin ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: China; ethnology; Coronary Disease; blood; genetics; Gene Frequency; Humans; Intercellular Adhesion Molecule-1; blood; genetics; Polymorphism, Genetic; Potassium; antagonists & inhibitors
- From: Chinese Journal of Medical Genetics 2006;23(2):195-197
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the linkage between K469E polymorphism of intercellular adhesion molecule 1(ICAM1) gene with ICAM1 plasma level and coronary heart disease (CHD) in Han population of China.
METHODSOne hundred and sixty-four controls without CHD and 160 patients with CHD were enrolled in our study. By nested PCR with allele-specific oligonucleotide primers, all patients and controls were genotyped for the ICAM1 polymorphism. And the ICAM1 plasma level was measured by ELISA.
RESULTSIn the patients with CHD, both K allele frequency and the plasma level of ICAM1 were higher than those in control (P<0.05). The individual with K allele had higher plasma level of ICAM1 than that without K allele (344.34+/-128.59 microg/L vs 303.54+/-108.74 microg/L, P=0.008). K allele enhanced the risk of CHD (P<0.01, OR=2.158, 95%CI: 1.250-3.727). There was the K allele cooperation with smoking in influencing the risk of CHD.
CONCLUSIONThere is the polymorphism of ICAM1 K469E gene in Han population of China, and the K allele may be a genetic factor influencing the risk of CHD.
