Polymorphism of vitamin D receptor gene Fok I in Mongolian population of China.
- Author:
Shao-ji XING
1
;
Li-she ZHOU
;
Xiu-ju XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; genetics; China; ethnology; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Population; Population Groups; genetics; Receptors, Calcitriol; genetics
- From: Chinese Journal of Medical Genetics 2006;23(2):236-237
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the polymorphism distribution of vitamin D receptor (VDR) gene Fok I in Mongolian population of China.
METHODSPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze three genotypes FF, Ff and ff in the start codon of VDR gene (Fok I) in unrelated normal healthy Mongolian individuals of China.
RESULTSIn the population, we obtained the allelic frequencies of 57% and 43% for (F) and (f) allele and the percentage of genotypes FF, Ff and ff to be 31%, 52%, and 17% respectively.
CONCLUSIONThe polymorphism frequency and distribution of this VDR gene Fok I in Mongolian population of China exhibit its own characteristics.
