Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China.

Author: Qing-hua WANG ¹ ; Wei-zhen CHEN ; Jian-ming TAN
Author Information

1. Department of Urology, Fuzhou General Hospital, Nanjing Command of PLA, Fuzhou, Fujian, 350025 P.R.China.
Publication Type:Journal Article
MeSH: Alleles; Asian Continental Ancestry Group; genetics; China; ethnology; Ethnic Groups; Gene Frequency; genetics; Genetics, Population; Geography; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Polymorphism, Genetic; Population Groups
From: Chinese Journal of Medical Genetics 2006;23(2):240-241
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the HLA-DRB1 allele polymorphism in Fujian Han nationality population.
METHODSSix hundred and twenty individual samples collected from unrelated Fujian Han population were subjected to genotyping using oligonucleotide microarray technique. And the allele frequencies of HLA-DRB1 were calculated and compared with other populations.
RESULTSFourteen HLA-DRB1 alleles of Fujian Han population were detected. The gene frequencies ordered from high to low were HLA-DRB1*9, 12, 15, 4, 8 respectively.
CONCLUSIONThe HLA-DRB1 distribution of Fujian Han population shares some genetic characters with southern Chinese Han populations, but these characters differ from northern Chinese populations.