Polymorphism of CYP1A1 gene Msp I site in the Mongolian and Han nationality populations of Inner Mongolia of China.
- Author:
Fu-hou CHANG
1
;
Ting-mao HU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Binding Sites; genetics; China; Cytochrome P-450 CYP1A1; genetics; Deoxyribonuclease HpaII; metabolism; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Mongolia; ethnology; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; Young Adult
- From: Chinese Journal of Medical Genetics 2006;23(3):333-334
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the polymorphism of CYP1A1 gene Msp I site in the Mongolian and Han nationality populations of Inner Mongolia.
METHODSThe PCR-restriction fragment length polymorphism(PCR-RFLP) technique was used to analyze the genotypes of CYP1A1 gene Msp I site in 80 subjects of Mongolian nationality and 120 subjects of Han nationality among whom there is no blood relationship each other.
RESULTSThe genotype frequency of CYP1A1 gene Msp I site showed that the wild-type, heterozygote, homozygous variants were 35.0%, 48.7%, 16.3% and 33.3%, 52.5%, 14.2% respectively distributions of Mongolian nationality and Han nationality population, and the Chi-square tests showed that there was no significant difference between the two groups.
CONCLUSIONThe genotype frequency distributions of CYP1A1 gene Msp I site did not exhibit the obvious difference between Mongolian nationality and Han nationality population of Inner Mongolia.
