Effects of the active components of some Chinese herbs on drug metabolizing-enzymes.
- Author:
Xiu-fen YANG
1
;
Nai-ping WANG
;
Fan-dian ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cytochrome P-450 Enzyme System; metabolism; Flavonoids; isolation & purification; pharmacology; Furocoumarins; isolation & purification; pharmacology; Glucuronosyltransferase; metabolism; Glutathione Transferase; metabolism; Humans; Plants, Medicinal; chemistry; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2002;27(5):325-328
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo review the effects of the active components of Chinese herbs on drug metabolizing-enzymes.
METHODRelevant research papers reported in recent years were consulted and studied.
RESULTThe drug metabolizing-enzymes cytochrome P450 and UDP-glucuronosyl transferase and glutathione S-transferase were inhibited or induced by the flavonoids, furocoumarins, and the active components extracted from salvia miltiorrhiza and hypericum perforatum, and so on, which therefore slowed or sped metabolism of other drugs in vivo and in vitro.
CONCLUSIONMuch attention should be paid to the metabolic interaction of the Chinese herbs when coadministered with other drugs.
