Preparation of genistein-loaded chitosan microspheres.
- Author:
Wan-ying WU
1
;
Yun-gu LI
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; administration & dosage; Chitin; analogs & derivatives; Chitosan; Delayed-Action Preparations; Genistein; administration & dosage; Mathematics; Microspheres
- From: China Journal of Chinese Materia Medica 2002;27(5):353-355
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the preparation of genistein chitosan microspheres with central composite design (CCD).
METHODThe chitosan microspheres were prepared by the O/W/O multiple emulsion method. Second-order polynomial and linear equations were fitted to the data, and the resulting equations were used to produce response surface graphs and the best experiment conditions.
RESULTThe theoretical drug content was 13%-15%, the concentration of organic phase was 30%-40% and the concentration of oil phase was 68%-72%.
CONCLUSIONThe best experiment conditions can be obtained by central composite design and response surface methodology. The observed values agree well with model predicted values.
