The effect of shourong compound formula on levels of dopamine and its metabolites in brain of Parkinson's disease mice induced by reserpine.
- Author:
Wei WANG
1
;
De-zhong ZHAO
;
Xiao-fang SUN
;
Sheng-dong GU
Author Information
- Publication Type:Journal Article
- MeSH: 3,4-Dihydroxyphenylacetic Acid; metabolism; Animals; Benserazide; pharmacology; Brain; metabolism; Dopamine; metabolism; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Homovanillic Acid; metabolism; Levodopa; pharmacology; Male; Mice; Parkinson Disease, Secondary; chemically induced; metabolism; Plant Extracts; pharmacology; Plants, Medicinal; chemistry; Reserpine
- From: China Journal of Chinese Materia Medica 2002;27(5):368-370
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Shourong compound formula on treating Parkinson's disease.
METHODParkinson's disease model mice induced by reserpine was used and by HPLC-ED the levels of Dopamine (DA) and its metabolites were determined.
RESULTMadopar could increase the levels of DA in brain of PD mice. The effect of madopar together with Sourong compound formula was better than that of madopar(P < 0.001).
CONCLUSIONShourong compound formula together with madopar has synergic effect on increase of DA level in brain and can reduce clinic dose of madopar so that side effect of madopar can be decreased.
