Protective effects and its mechanism of panaxatriol saponins isolated from Panax notoginseng on cerebral ischemia.
- Author:
Xiao-hao YAO
1
;
Xue-jun LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; metabolism; Ginsenosides; isolation & purification; pharmacology; HSP70 Heat-Shock Proteins; metabolism; Infarction, Middle Cerebral Artery; metabolism; Male; Neuroprotective Agents; pharmacology; Panax; chemistry; Plants, Medicinal; chemistry; Rats; Transferrin; metabolism; Triterpenes; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2002;27(5):371-373
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effects and its mechanism of Panaxatriol Saponins isolated from Panax notoginseng (PTS) on focal cerebral ischemia in rat brain.
METHODThe influences of PTS on cerebral water content and three specific proteins (VEGF, HSP70 and transferrin) related with cerebral ischemia were studied with unilateral occlusion of the middle cerebral artery (MCAO) and Western Blot.
RESULTPTS 12.5 mg.kg-1 i.p. x 7 d (5 d before MCAO and 2 d after MCAO) inhibited the increase of cerebral water content caused by MCAO and influenced contents of HSP70 and transferrin, but had no influence on VEGF protein level.
CONCLUSIONPTS shows a protective effect on focal cerebral ischemia in rat brain by alleviating cerebral edema, up-regulating the expression of HSP70, down-regulating transferrin and maintaining blood-brain barrier.
