Effect of protein and anthraquinone glucosides from cassia seed on serum lipid of hyperlipidemia rats.
- Author:
Xu-e LI
1
;
Bao-jiang GUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anthraquinones; isolation & purification; pharmacology; Cassia; chemistry; Cholesterol; blood; Cholesterol, LDL; blood; Female; Hyperglycemia; blood; Hypoglycemic Agents; isolation & purification; pharmacology; Male; Plant Proteins; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Rats; Seeds; chemistry; Triglycerides; blood
- From: China Journal of Chinese Materia Medica 2002;27(5):374-376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of protein and anthraquinone glucosides from cassia seed on serum lipid of hyperlipidemia rats.
METHODThe rat hyperlipidemia model was set up by ig lipid emulsion. The effects of the protein 0.25 and 1 mg.kg-1. d-1, the anthraquinone glucosides 5 and 20 mg.kg-1.d-1, and the protein 0.25 mg.kg-1.d-1 plus the anthracene glucosides 5 mg.kg-1.d-1 on total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) in serum of the rats were determined.
RESULTThe protein 1 mg.kg-1.d-1, the anthraquinone glucosides 20 mg.kg-1.d-1 reduced the raised TC, TG, LDL-C of hyperlipidemia rats (P < 0.05). The above indexes could also be reduced by the protein 0.25 mg.kg-1.d-1 plus the anthraquinone glucosides 5 mg.kg-1.d-1(P < 0.05, P < 0.01).
CONCLUSIONProtein and anthraquinone glucosides from cassia seed can lower TC, TG, LDL-C of hyperlipidemia rats.
