Novel role of microRNAs in prostate cancer.

Author: Jun-jie YU ¹ ; Shu-jie XIA
Author Information

1. Department of Urology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
Publication Type:Journal Article
MeSH: Biomarkers; analysis; Drug Resistance, Neoplasm; Humans; Male; MicroRNAs; analysis; physiology; Prostatic Neoplasms; diagnosis; drug therapy; pathology
From: Chinese Medical Journal 2013;126(15):2960-2964
CountryChina
Language:English
Abstract:
OBJECTIVETo discuss the novel biomarkers of microRNAs in prostate cancer.
DATA SOURCESThe literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012.
STUDY SELECTIONOriginal articles regarding the novel role of microRNAs in prostate cancer were selected.
RESULTSMicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction.
CONCLUSIONSMicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.