Effects of L-nitroarginine on the recovery of traumatic facial paralysis.
- Author:
Li-jun WANG
1
;
Shu-xia ZHOU
;
Chang-kai SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Facial Injuries; complications; Facial Paralysis; drug therapy; Male; Membrane Glycoproteins; analysis; Nitric Oxide; physiology; Nitric Oxide Synthase; analysis; Nitroarginine; therapeutic use; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Stomatology 2003;38(6):447-449
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of constitutive nitric oxide synthase inhibitor L-nitroarginine on the recovery of traumatic facial paralysis in rats and the changes of the expression of cNOS and OX42 in the facial nucleus.
METHODSL-nitroarginine was intraperitoneally injected into rats and the recovery of facial paralysis was observed at different time point. and the changes of cNOS and OX42 positive neurons were studied in facial nucleus.
RESULTSTreatment of L-nitroarginine could remarkably inhibit the recovery of traumatic facial paralysis. The cNOS immunoactivity was obvious inhibited in facial nucleus, while the OX42 immunoactivity was obvious increased.
CONCLUSIONEndogenous nitric oxide may play an important mediator role on the recovery of traumatic facial paralysis.
