A pilot study of repair of periodontal bone defects with carbonated phosphate bone cement modified with synthesized peptides in dogs.
- Author:
Jiang-hai NING
1
;
Hong-chen LIU
;
Ke-ya MAO
;
He-ping PAN
;
Hui-xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Alveolar Bone Loss; therapy; Animals; Bone Cements; Bone Regeneration; Bone Substitutes; Calcium Phosphates; Dogs; Durapatite; Male
- From: Chinese Journal of Stomatology 2003;38(6):464-466
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possibility of repairing periodontal defects with carbonated calcium phosphate bone cement (CCPBC) modified with synthesized peptides.
METHODSPeriodontal bone defects in 4 dogs were surgically created and then restored directly with hydroxyapatite (HA), Perioglass, CCPBC and CCPBC modified with peptides. The results were compared at different levels.
RESULTSBone replacement materials were lost in HA and Perioglass groups. In the HA group defects were restored with connective tissue. Perioglass group had only a little new bone around materials by alveolar bone. CCPBC could firmly stay in bone defects to maintain the space of bone defects even without membrane use. CCPBC modified with peptides was superior to HA, Perioglass, and CCPBC, surrounded by a great deal of new bone.
CONCLUSIONUnder limitation of this study, CCPBC modified with peptides has some osteoinuctive activity and may have good prospect for the clinical application in periodontal defect repair.
