The study of the invasive biologic behavior of ameloblastoma.
- Author:
Ming ZHONG
1
;
Zi-Juan LI
;
Jie WANG
;
Yang-Li YUE
;
Gang BAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Ameloblastoma; chemistry; pathology; Cadherins; analysis; Child; Female; Humans; Jaw Neoplasms; chemistry; pathology; Male; Matrix Metalloproteinase 2; analysis; Matrix Metalloproteinase 9; analysis; Middle Aged; Neoplasm Invasiveness; Vascular Endothelial Growth Factor A; analysis
- From: Chinese Journal of Stomatology 2004;39(1):45-48
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the invasive biologic behavior of ameloblastoma (AB) and to analyze its correlative factors.
METHODSThe specimens of 43 cases of AB (primary AB 16 cases, recurrent AB 21 cases, malignant AB 6 cases) were examined immunohistochemically using the streptavidin-biotin method to determine the expression of E-cadherin (E-cad), matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor (VEGF).
RESULTSThe cells in malignant AB scattered more, grew invasively, and the basal membrane ruptured or lost. The expression of E-cad in AB descended, MMP-2 and MMP-9 were strongly expressed in the epithelia cells of 28/41, 30/43 cases of AB, respectively. The positive rate and intensity of VEGF increased as AB recurred and transformed malignantly. The expression of E-cad, MMP-9 and VEGF were related to recurrence or malignant transformation of AB (r(s) = 0.309, 0.519, 0.381, P < 0.05).
CONCLUSIONAB is a high invasive tumor. The biological behavior of AB is related to lost or abnormal expression of E-cad, the high expression of MMP-2, MMP-9, and VEGF.
