The study of proliferation of cells at the invasive tumor front of squamous cell carcinoma of tongue.
- Author:
Xin-Hong WANG
1
;
Shuo-Zhi WANG
;
Xin-Ming CHEN
;
Yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; pathology; Cell Division; Female; Humans; Ki-67 Antigen; analysis; Male; Middle Aged; Neoplasm Invasiveness; Nucleolus Organizer Region; pathology; Proliferating Cell Nuclear Antigen; analysis; Tongue Neoplasms; pathology
- From: Chinese Journal of Stomatology 2004;39(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of the invasive front grading (IFG), the proliferative activity of cells at the invasive tumor front (ITF) of squamous cell carcinoma (SCC) of tongue.
METHODSAll the tumors were graded using IFG grading. The expression of PCNA, Ki67 and staining and measurement of AgNOR number were evaluated at the ITF and the other parts of the same tumor.
RESULTSThe expression of PCNA (P < 0.001), Ki67 (P < 0.001), AgNOR number (P < 0.001) at the ITF were higher than those of other parts. The IFG score was significantly correlated with the expression of PCNA (P < 0.05), AgNOR number (P < 0.01) at the ITF. The complete IFG score (P < 0.01) was significant in both univariate and multivariate cox analysis; the AgNOR number at the ITF (P < 0.05) was only significant in univariate analysis (P < 0.05).
CONCLUSIONSThe ITF of SCCs of tongue differentiate poorer than the other parts and is active in proliferation. The complete IFG score and the AgNOR number at the ITF could be a valuable indication to predict the prognosis of SCCs of tongue.
