The relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma.
- Author:
Zhi-jian XIE
1
;
Xiao-feng YANG
;
Jun FAN
;
Yin-kai ZHANG
;
Qiu-liang WU
;
Zhi-yuan GU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; secondary; surgery; Humans; Lymph Node Excision; Lymph Nodes; pathology; Lymphangiogenesis; Lymphatic Metastasis; Mouth Neoplasms; pathology; surgery; Neck
- From: Chinese Journal of Stomatology 2004;39(3):221-223
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo probe the relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma.
METHODSThe microlymphatic vessel density was detected with enzyme histo-chemical method in 47 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa; 355 lymphnodes were detected with immunohistochemically using monoantibody AE3.
RESULTSThe mean MLVD was 14.04 +/- 6.92 in tumor group, or 5.48 +/- 2.62 in normal group. The difference was (P < 0.001). The percentage of tumor with expression CK was 48.9%. The mean MLVD was 16.94 +/- 5.43 in CK positive group, or 11.26 +/- 5.00 in CK negative group, There was difference significant (P < 0.001).
CONCLUSIONSLymphangiogenesis plays a key role in cervical lymph node micrometastasis of oral squamous cell carcinoma.
