Clinical analysis for 3 cases of HLA-matched between father and son and 1 case of post-hematopoietic stem cell transplant efficacy.
- Author:
Hong-Yan WANG
1
;
Hong-Shi JIN
;
Yuan-Yuan XU
;
Yi DING
;
Jing-Fen SUN
;
Li-Li WANG
;
Li YU
Author Information
1. Department of Hematology, Chinese PLA General Hospital, Beijing, China.
- Publication Type:Case Reports
- MeSH:
Fathers;
HLA Antigens;
genetics;
immunology;
Hematopoietic Stem Cell Transplantation;
methods;
Histocompatibility Testing;
Humans;
Living Donors;
Male;
Pedigree;
Transplantation Conditioning;
methods;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(2):416-420
- CountryChina
- Language:Chinese
-
Abstract:
Getting a HLA-matched donor is a key factor for successful hematopoietic stem cell transplantation. People are almost semi-matched with their parents, while a person HLA-matched with his/her father or mother was rarely seen, if so, usually whose father and mother are genetically related. HLA-low resolution for patients and their relatives were performed using PCR-SSP technique and three patients were found HLA-matched with their father in these results. One of them accepted hematopoietic stem cell transplantation using his HLA-matched father as his donor. The results showed that the chimerism was detected as stable complete donor chimerism, fusing gene of MLL-ENL was detected all negatively in the post-transplant period. This case got well hematopoietic reconstruction and GVHD didn't occur, so far he has survived for two years in health conditioning. It is concluded that people HLA-matched with his/her father or mother can be found when there is one identical haplotype of high frequency and strong linkage disequilibrium between father and mother. This case is valuable for hematopoietic stem cell transplantation development.
