Co-evolutionary analysis on strategy for therapy of spreading cancer.
- Author:
Ke-Fu WU
1
;
Guo-Guang ZHENG
;
Xiao-Tong MA
;
Xiao-Fan ZHU
;
Ye GUO
;
Yu-Hua SONG
Author Information
1. Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences, Tianjin, China. hiwukefu@163.com
- Publication Type:Journal Article
- MeSH:
Biological Evolution;
Game Theory;
Neoplasms;
therapy
- From:
Journal of Experimental Hematology
2012;20(3):523-526
- CountryChina
- Language:Chinese
-
Abstract:
Evolutionary medicine can give rational explanation for metabolism diseases via ecology and evolutionary theory. Recently, the view of somatic cell macroevolution was used in the study on the genesis and development of tumors, which provided new insight in the research work on tumors. In this article, the well-adopted tumor therapy strategy, "Dancing with Cancer", was analyzed preliminarily from the point of co-evolution game theory, based on the non-classical immunology theory and genome theory. The importance of increasing host fitness by changing host life-style to enhance tolerance was emphasized, which is the basis of the Dancing with Cancer strategy. On the other hand, the spreading tumor cells are not equally malignant and spreading tumors should be treated as other chronic diseases. Finally, basic and clinical research should be strengthened to improve the efficiency of the "Dancing with Cancer" strategy.
