Expression of transforming growth factor-β1 and its receptors in peripheral blood of patients with immune thrombocytopenic purpura.
- Author:
Zhi FANG
1
;
Yi-Zhuo ZHANG
;
Ting CAI
;
Ke-Qiang LI
;
Jing YU
;
Yang-Qing LUO
;
Hai-Feng ZHAO
Author Information
1. Department of Hematology and Oncology, Ningbo Municipal Second Hospital, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Case-Control Studies;
Child;
Female;
Humans;
Male;
Middle Aged;
Protein-Serine-Threonine Kinases;
metabolism;
Purpura, Thrombocytopenic, Idiopathic;
metabolism;
pathology;
Receptors, Transforming Growth Factor beta;
metabolism;
Transforming Growth Factor beta1;
metabolism;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(3):664-666
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to detect the expression of transforming growth factor β1 (TGF-β1) and its receptors (TGF-βR) and to investigate their roles in pathogenesis of immune thrombocytopenic purpura (ITP). The expressions of TGF-β1 and their receptors TGF-βRI, TGF-βRII and TGF-βRIII in the peripheral blood of patients with ITP and healthy persons were detected by the real-time PCR, and differences of their expression levels were analysed. The results showed that the expression of TGF-β1 and TGF-βRII mRNA in ITP patients was significantly higher than that in the healthy controls, while the TGF-βRI mRNA expression in ITP patient was significantly lower than that in the controls. The expression of TGF-βRIII was not statistically different between the two groups. It is concluded that TGF-β1 and its receptors including TGF-βRI and TGF-βRII express abnormally in the peripheral blood of ITP patients, which suggests that the TGF-β signaling pathway probably play a vital role in the pathogenesis of the ITP.
