Research progress on immunocyte senescence - review.
- Author:
Bo YANG
1
;
Xiao-Hua CHI
;
Xue-Chun LU
;
Shuai TUO
;
Feng ZHANG
;
Wen-Ying ZHANG
;
Chao-Wei TUO
;
Wei-Dong HAN
;
Shan-Qian YAO
Author Information
1. Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Age Factors;
Aging;
immunology;
Antibody Formation;
immunology;
Cellular Senescence;
Humans;
Immunity, Cellular;
immunology;
Lymphocyte Activation
- From:
Journal of Experimental Hematology
2012;20(3):782-787
- CountryChina
- Language:Chinese
-
Abstract:
The function of immune system degenerates in an aging-dependent manner and this results in immunosenescence. Human immune system includes two parts: genetic/innate immunity and adaptive immunity. The former is involved in monocytes, nature killer cells, and dendritic cells, the later is involved in acquired B and T lymphocytes. During the aging of immunity system, the both parts of immunity are damaged to some degree. Generally, innate immunity seems well-retained and the acquired immunity is degenerative seriously with aging. Immunocyte senescence is closely related to the elderly decreased ability to control infectious disease, cancer and to their generally poor response to vaccination. This review summarized the research progress on immunosenescence characteristics in aged phase.
