Catalytic activity of Bence Jones proteins in renal impairment of patients with multiple myeloma - review.
- Author:
Xiao ZHOU
1
;
Yong-Ping ZHAI
Author Information
1. Department of Hematology, Southem Medical University, Nanjing, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Bence Jones Protein;
metabolism;
Humans;
Kidney;
pathology;
LLC-PK1 Cells;
Multiple Myeloma;
metabolism;
pathology;
Swine
- From:
Journal of Experimental Hematology
2012;20(3):796-800
- CountryChina
- Language:Chinese
-
Abstract:
Renal impairment is one of frequent and serious complications in patients with multiple myeloma (MM) and is associated with a higher incidence of infections and early death rate. The catalytic activity of Bence Jones proteins (BJP) affects the clinical processes of patients with MM, and can lead to renal impairment. Scientists point out that BJP have peptidolytic and nucleolytic activity, which can lead porcine kidney proximal tubule (LLC-PK1) to apoptosis in vitro experiments. By treating the cytotoxic BJP with serine protease inhibitor (DFP), BJP lost not only their catalytic activity, but also the cytotoxic effects. Therefore, further research on BJP will helpful to understand the pathogenesis of renal impairment in MM patients and may provide a new idea and measure for the treatment of MM with renal impairment. This article reviews the basic research and progress on the catalytic activity of BJP.
