Study on vitro release and transdermal behaviors of Yulian cataplasm.
- Author:
Maobo DU
1
;
Shuzhi LIU
;
Manling LI
;
Rixian JIN
;
Chen KANG
;
Junhong LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Berberine; administration & dosage; pharmacokinetics; Berberine Alkaloids; administration & dosage; pharmacokinetics; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Indole Alkaloids; administration & dosage; pharmacokinetics; Mice; Plant Extracts; administration & dosage; pharmacokinetics; Quinazolines; administration & dosage; pharmacokinetics; Skin; metabolism; Skin Absorption
- From: China Journal of Chinese Materia Medica 2009;34(8):969-972
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the regularity of Yulian Cataplasm in vitro release and transdermal behaviors.
METHODImproved Franz diffusion devices was used with four index ingredients as evodiamine, rutaecarpine, palmatine and berberine that were determined by HPLC in one mobile phase.
RESULTThe release rates of evodiamine, rutaecarpine, palmatine and berberine were 0.0239, 0.0156, 0.0725, 0.8191 mg x cm(-2) x h(-1/2), respectivley. The transdermal rates of evodiamine, rutaecarpine, palmatine and berberine were 1.256, 1.0302, 2.8029, 20.919 microg x cm(-2) x h(-1), respectively.
CONCLUSIONThe releasing process of all index is in accordance with Higuchi equation and the transdermal proccess is in accordance with zero-level equation.
