Studies on chemical constituents in fruit of Alpinia oxyphylla.
- Author:
Junju XU
1
;
Ninghua TAN
;
Guangzhi ZENG
;
Hongjin HAN
;
Huoqiang HUANG
;
Changjiu JI
;
Meiju ZHU
;
Yumei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Alpinia; chemistry; Benzaldehydes; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; Cell Survival; drug effects; Diarylheptanoids; chemistry; isolation & purification; pharmacology; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; Flavonoids; chemistry; isolation & purification; pharmacology; Fruit; chemistry; Guaiacol; analogs & derivatives; chemistry; isolation & purification; pharmacology; HT29 Cells; Humans
- From: China Journal of Chinese Materia Medica 2009;34(8):990-993
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents in fruit of Alpinia oxyphylla and their cytotoxicities on cancer cell lines.
METHODCompounds were isolated and purified by various column chromatographic methods. Their structures were determined by physico-chemical properties and spectral analyses. Compound cytotoxicity was assessed by the sulforhodamine B (SRB) assay.
RESULTEight compounds were obtained from Me2CO-H2O (70%) extract of the fruit of A. oxyphylla and their structures were identified as: (9E)-humulene-2, 3; 6, 7-diepoxide (1), 3(12), 7(13), 9(E)-humulatriene-2, 6-diol (2), (-)-oplopanone (3), yakuchinone A (4), yakuchinone B (5), tectochrysin (6), isovanillin (7), (2E, 4E)-6-hydroxy-2, 6-dimethylhepta-2, 4-dienal (8), and the cytotoxicities of compounds 1, 3-5 on cancer cell lines, A549, HT-29 and SGC-7901, were also investigated.
CONCLUSIONCompounds 1-3, 7, 8 were isolated for the first time from this genus and compounds 1, 3-5 exhibited no cytotoxicity against three cancer cell lines at a concentration of 10 mg x L(-1).
