Chemical constituents of Alisma orientalis and their immunosuppressive function.
- Author:
Chaofeng ZHANG
1
;
Aichun ZHOU
;
Mian ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Alisma; chemistry; Animals; Cells, Cultured; Cholestenones; chemistry; pharmacology; Drugs, Chinese Herbal; chemistry; pharmacology; Immunosuppressive Agents; chemistry; pharmacology; Indoles; chemistry; pharmacology; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Sesquiterpenes; chemistry; pharmacology; T-Lymphocytes; cytology; drug effects; Triterpenes; chemistry; pharmacology
- From: China Journal of Chinese Materia Medica 2009;34(8):994-998
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents with immunosuppressive function from Alisma orientalis.
METHODThe chemical constituents were isolated and purified by kinds of column chromatography and its structures were elucidated by NMR spectra and physicochemical properties. Its immunocompentence of lymphocytes taken from spleen of mouse were examined by MTT assay.
RESULTTwelve compounds were isolated and identified as clovandiol (1), orientalol E (2), alismoxide (3), alismol (4), 4alpha, l0alpha-dihydroxy-5beta-H-guaj-6-en (5), alismorientols A (6), alisol F (7), alisol A (8), 13beta,17beta-epoxy alisol A (9), alisol B 23-acetate (10), 1H-indole-3-carboxylic acid (11) and cuccinic acid (12). Compounds 9, 10 and alisol A 24-acetate showed immunosuppressive function.
CONCLUSIONCompounds 1, 5, 11 and 12 were isolated firstly from this genus,and the NMR spectra data of 1 were corrected firstly, some protostan-type triterpenoids may be developed as new drug with immunosuppressive function.
