Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets.
- Author:
Xiaoyan LI
1
;
Zhong FENG
;
Wuzhen HUO
;
Yuanxin LI
;
Bo WANG
;
Shengshan ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; chemistry; Drug Carriers; Drug Compounding; Drug Stability; Ephedrine; chemistry; Hardness; Hydrogen-Ion Concentration; Kinetics; Pharmaceutical Preparations; chemistry; Solubility; Spectrophotometry, Ultraviolet; Tablets; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(10):1216-1219
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets.
METHODThe ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not.
RESULTCompared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h.
CONCLUSIONThe maker components of Zhike Pingchuan sustained-release tablets and two chromatographic conditions, which were used to determine the dissolution of the sustained-release tablets, could be chosen as evaluation methods for the in vitro release of Zhike Pingchuan sustained-release tablets.
