Study on chemical constituents from roots of Saussurea lappa.

Author: Ting ZHANG ¹ ; Hongqing WANG ; Guanhua DU ; Ruoyun CHEN
Author Information

1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
MeSH: Benzaldehydes; chemistry; isolation & purification; Palmitic Acid; chemistry; isolation & purification; Plant Roots; chemistry; Pyrrolidinones; chemistry; isolation & purification; Saussurea; chemistry; Sitosterols; chemistry; isolation & purification
From: China Journal of Chinese Materia Medica 2009;34(10):1223-1224
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the chemical constituents in roots of Saussurea lappa.
METHODIsolation and purification were carried out by silica gel, Sephadex LH-20 and RP-18 column chromatography. The chemical structures of constituents were elucidated on the basis of spectral data.
RESULTEleven compounds were isolated and identified as: 5,7-dihydroxy-2-methylchromone (1), p-hydroxybenzaldehyde (2), 3,5-dimethoxy-4-hydroxy-benzaldehyde (3), 3,5-dimethoxy-4-hydroxy-acetophenone (4), ethyl 2-pyrrolidinone-5(s)-carboxylate (5), 5-hydroxymethyl-furaldehyde (6), palmitic acid (7), succinic acid (8), glucose (9), daucosterol (10), beta-sitosterol (11).
CONCLUSIONCompounds 1, 2, 4, 5, 7, 9 were isolated from the genus Saussurea for the first time.