Effect of Cynomorium songaricum polysaccharide on telomere length in blood and brain of D-galactose-induced senescence mice.
- Author:
Lijie MA
1
;
Guilin CHEN
;
Lisha NIE
;
Min AI
Author Information
- Publication Type:Journal Article
- MeSH: Aging; drug effects; Animals; Animals, Newborn; Brain; drug effects; pathology; Cellular Senescence; drug effects; Cynomorium; chemistry; Disease Models, Animal; Drugs, Chinese Herbal; therapeutic use; Galactose; pharmacology; Humans; In Situ Hybridization, Fluorescence; Mice; Polysaccharides; pharmacology; therapeutic use; Telomere; drug effects; physiology
- From: China Journal of Chinese Materia Medica 2009;34(10):1257-1260
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Cynomorium songaricum polysaccharide (CSP) on telomere length in blood and brain tissues of aged mice in order to provide some evidence for CSP's development and applying in the clinical uses.
METHODKunming mice were intraperitoneal injected D-galactose (500 mg x kg(-1) x d(-1)) to make the aging models, and different dosages of CSP (20, 40, 80 mg x kg(-1)) were given by gavage for 56 days. The average length of telomere was determined by real-time fluorescence quantitative PCR.
RESULTThe relative T/S ratio of the group high and middle dosages of CSP in blood were 1.64 +/- 0.36 and 1.33 +/0.28, respectively, and higher than that of the group of senescence 1.01 +/- 0.13 (P < 0.01). Values of the group of high, middle, and low dosages of CSP in brain tissues were 3.34 +/- 0.58, 2.30 +/- 0. 75 and 1.55 +/- 0.58, respectively, and significantly higher than that of the group of senescence 1.04 +/- 0.33 (P < 0.01).
CONCLUSIONCSP can exert the anti-aging effects by increase telomere length f senescence mice.
