In vitro activity of gallic acid against Candida albicans biofilms.
- Author:
Changzhong WANG
1
;
Huijuan CHENG
;
Yan GUAN
;
Yan WANG
;
Yun YUN
Author Information
- Publication Type:Journal Article
- MeSH: Biofilms; drug effects; Candida albicans; cytology; drug effects; physiology; Cell Adhesion; drug effects; Dose-Response Relationship, Drug; Gallic Acid; pharmacology
- From: China Journal of Chinese Materia Medica 2009;34(9):1137-1140
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of gallic acid against Candida albicans biofilms in vitro.
METHODXTT reduction assay was performed to determine the effect of gallic acid on C. albicans biofilms and its adherence, and microscopic examination was conducted to assess the effect of gallic acid on morphogenesis of C. albicans biofilms; and cytotoxic assay was used to measure the adverse effects of gallic acid.
RESULTSMIC50, SMIC50 of gallic acid against C. albicans biofilms were 500, 1000 mg x L(-1), respectively; 100 mg x L(-1) and 1000 mg x L(-1) of gallic acid could inhibit the initial adherence and filamentous growth, and the agent showed poor cytotoxic activity.
CONCLUSIONgallic acid displayed potent activity against C. albicans biofilm.
