Preparation and prescription of enteric coated pellets of Panax notoginseng saponins pellets.
- Author:
Chunhua LAI
1
;
Qin ZHENG
;
Ming YANG
;
Pengyi HU
;
Junjie PAN
;
Changchun PENG
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; methods; Drug Stability; Gastric Acid; chemistry; Gastrointestinal Tract; drug effects; Humans; Models, Biological; Panax notoginseng; chemistry; Saponins; chemistry; pharmacokinetics; Tablets, Enteric-Coated; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(11):1359-1363
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare enteric coated pellets containing panax notoginseng saponins.
METHODPanax notoginseng saponins loaded pellets were prepared by Extrusion-Spheronization method, and coated by Eudragit L30D-55 using Glatt fluid bed with the bottom spray process, central composite design was used to optimize the coating prescription.
RESULTThe drug release of enteric coated pellets of panax notoginseng saponins pellets would be lower than 5% in 2 h in simulated gastric fluid, but reach above 85% in 3 h in simulated human gastroenteric environment.
CONCLUSIONThe enteric coated pellets of panax notoginseng saponins have good acid residence to avoid panax notoginseng saponins from degrading in gastric acid.
