Preparation and characterization of solid dispersions of ginkgolides.
- Author:
Linyi MA
1
;
Limei HAN
;
Zhirong ZHANG
;
Jianxin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Calorimetry, Differential Scanning; Ginkgolides; chemistry; Pharmaceutical Preparations; chemistry; Solubility; X-Ray Diffraction
- From: China Journal of Chinese Materia Medica 2009;34(11):1368-1372
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the preparation process of solid dispersions of ginkgolides to improve the drug dissolution.
METHODThe influence of formulation and preparation technology on drug release from solid dispersions was investigated by single factor test. The X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) were used to characterize the solid dispersions of ginkgolides.
RESULTThe solubilization efficiency of solid dispersions using PVP k30 as carrier was better than that taking poloxamer 188 or HPMC as matrix. The results of XRD and DSC showed that ginkgolides existed in solid dispersion at amorphous form or solvates form. The dissolution rate of ginkgolide B in solid dispersion was increased dramatically compared with raw material.
CONCLUSIONSolid dispersions could significantly improve solubility and dissolution rate of ginkgolides.
