Ligans from branch of Hypericum petiolulatum.
- Author:
Qi ZHAO
1
;
Juan LIU
;
Funan WANG
;
Guifan LIU
;
Guizhi WANG
;
Kun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Drugs, Chinese Herbal; chemistry; Hypericum; chemistry; Lignans; chemistry; Magnetic Resonance Spectroscopy; Mass Spectrometry
- From: China Journal of Chinese Materia Medica 2009;34(11):1373-1376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents of Hypericum petiolulatum.
METHODThe chemical constituents were isolated and purified by column chromatography on silica gel, macroporous adsorbent resin, Sephadex LH-20, and preparative HPLC. Structures of the compounds were identified by NMR and MS spectroscopic methods.
RESULTNine lignans were obtained and their structures were elucidated as (-)-(2R, 3R)-1-O-feruloyl-8,8'-bisdihydrosiringenin (1), (-) -secoisolariciresinol 4-O-beta-D-glucopyrano-side (2), isolariciresinol-beta-4'-O-beta-D-glucopyranoside (3), 5-methoxy-9beta-xylopyra-nosyl-(+) -isolariciresinol (4), (+) -lyoniresinol 2alpha-O-beta-D-xylopyranoside (5), 5-methoxy-9-beta-xylopyranosyl-(-) -isolariciresinol (6), isolariciresinol 6a-O-beta-D-gluco-side (7), (+)-lyoniresinol 3alpha-O-beta-D-xylopyranoside (8) and 7-methoxy-5-benzofuranpropanol 4'-O-beta-D-glucopyranoside (9).
CONCLUSIONCoupound 1 was new and compounds 2-9 were obtained from the genus Hypericum for the first time.
