Studies on antibacterial constituents of Discocleidion rufescens (2).
- Author:
Ye TIAN
1
;
Haifeng TANG
;
Xiaojuan WANG
;
Feng QIU
;
Gaijin XUE
;
Jun LI
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; analysis; isolation & purification; pharmacology; Escherichia coli; drug effects; Euphorbiaceae; chemistry; Plant Extracts; analysis; isolation & purification; pharmacology; Staphylococcus aureus; drug effects
- From: China Journal of Chinese Materia Medica 2009;34(11):1377-1380
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo screen effective constituents of Discocleidion rufescens against bacteria.
METHODCompounds were isolated by bioassay-guided fractionation method with various chromatographic methods and their structures were determined by spectral analysis and chemical evidence.
RESULTSeven compounds were isolated from the Et2O and n-BuOH extracts and identified as 5,7-dihydroxy-4'-methoxy flavone (1), quercetin (2), apigenin-7-O-beta-D-glucopyranoside (3), apigenin-7-O-neohesperidoside (4), luteolin-7-O-neohesperidoside (5), gallic acid (6) and beta-daucosteol (7).
CONCLUSIONCompounds 1-6 were isolated from genus Discocleidion for the first time and exhibited certain inhibitory activity against Escherichia coli. Compound 6 also showed antibacterial activity against Staphylococus aureus.
